Behind the Product
Sinusitis affects 35+ million people each year, making it one of the most prevalent health problems in the U.S.
This affects more people than heart disease or asthma.
The problem is people who aren’t sufferers don’t get it. Sinus problems are regarded as trivial. “Grab a tissue and suck it up.”
Sinusitis has a higher effect on quality of life than congestive heart failure, angina, chronic obstructive pulmonary disease, and back pain.
It’s true. Would you tell someone with congestive heart failure to “suck it up”? So then why do sufferers put up with it more than many other common conditions?
Sufferers are constantly searching for relief online. Many people have, and will, try anything.
Kimchi up the nose.
Baby shampoo nasal rinse.
Current medically-approved solutions are either…
Easy and Temporary or Difficult, Invasive, or Expensive
OTCs, sprays and rinses are most common. Difficult, invasive, or expensive solutions include diet change, microbiome transplant, surgery, or even moving.
Unfortunately, even solutions as invasive
and painful as surgery often do not result in long-term, or have unideal side effects.
That’s where we come in.
We strove to make a sinus solution that:
- Is easy to try
- Is easy to use
- Provides lasting relief without rebound
- Has No (or very minimal) side effects
- Is Non-Antibiotic
- Is natural and trustworthy
But none of that would matter if it didn’t work.
It does. And this is how:
Sure Sinus manipulates the sinus microbiome to restore immune homeostasis. Sure Sinus works to prevent dysbiosis, or microbial imbalance, within your sinus microbiome. It works with your body to solidify the mucosal immunology of the respiratory membranes in your sinus cavity.
The nature and composition of bacteria present in the sinus biome are important contributors to the development of host defenses against infection and allergic reaction. Data shows that probiotic supplementation modulates immune responses and can help lessen symptoms. Probiotics help your body find the balance between necessary and excessive defense mechanisms.
Using scientifically-backed ingredients, Sure Sinus is primarily composed of 4 different strains of Lactobacilli. Beneficial varieties of this bacteria produce vitamins and nutrients, boost immune response and protect against carcinogens and unhealthy bacteria.
The mixture of species developed for Sure Sinus are all naturally part of the human sinus biome, as either a keystone (has a disproportionately large effect on the community), a pioneer (are the first to colonize the niche after a disruption), or a dominant (a relatively high abundance in most people) species. The right mixture is very important to a healthy biome.
The chosen strains have been found to be natural, safe, and conducive to restoring your body’s sinus biome to its natural state. Having a sinus biome that is out of balance leads to many common symptoms of both acute and chronic sinusitis. Scientific studies have shown that sinus inflammation is associated with decreased sinus bacterial diversity and the then collateral enrichment of specific sinus pathogens. The included species have been shown to competitively exclude the habitation of certain harmful bacteria.
The probiotics within Sure Sinus primarily act through the production of antimicrobial compounds. For example, one included strain produces the protein reuterin, which acts as an antimicrobial compound by inducing oxidative stress in competing bacteria. The effects of this protein are aimed at eliminating competing microbes, giving the good bacteria an advantage in righting the biome.
Intranasal administration is key in regulating respiratory immune responses. Probiotic administration directly into the sinus biome will influence the host composition and function via antimicrobial production, changing PH levels, or through competitive colonization.
Want to dig a little deeper into the research and science behind Sure Sinus?
Check out any of the links to studies below.
- Abreu, Nicole A, et al. “Sinus Microbiome Diversity Depletion and Corynebacterium Tuberculostearicum Enrichment Mediates Rhinosinusitis.” Science Translational Medicine, U.S. National Library of Medicine, 12 Sept. 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC4786373/
- Cope, E K, and S V Lynch. “Novel Microbiome-Based Therapeutics for Chronic Rhinosinusitis.” Current Allergy and Asthma Reports, U.S. National Library of Medicine, Mar. 2015, www.ncbi.nlm.nih.gov/pubmed/25777787
- Cope, Emily K, et al. “Compositionally and Functionally Distinct Sinus Microbiota in Chronic Rhinosinusitis Patients Have Immunological and Clinically Divergent Consequences.” Microbiome, BioMed Central, 12 May 2017, www.ncbi.nlm.nih.gov/pubmed/28494786
- Lal, Devyani, et al. “Mapping and Comparing Bacterial Microbiota in the Sinonasal Cavity of Healthy, Allergic Rhinitis, and Chronic Rhinosinusitis Subjects.” International Forum of Allergy & Rhinology, U.S. National Library of Medicine, June 2017, www.ncbi.nlm.nih.gov/pubmed/28481057
- Mahdavinia, M, et al. “A Comprehensive Review of the Nasal Microbiome in Chronic Rhinosinusitis (CRS).” Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, U.S. National Library of Medicine, Jan. 2016, www.ncbi.nlm.nih.gov/pubmed/26510171
- “Probiotics: In Depth.” National Center for Complementary and Integrative Health, U.S. Department of Health and Human Services, 31 July 2018, nccih.nih.gov/health/probiotics/introduction.htm
- Ramakrishnan, Vijay R, et al. “Sinus Microbiota Varies among Chronic Rhinosinusitis Phenotypes and Predicts Surgical Outcome.” The Journal of Allergy and Clinical Immunology, U.S. National Library of Medicine, Aug. 2015, www.ncbi.nlm.nih.gov/pubmed/25819063
- Vickery, Thad W, and Vijay R Ramakrishnan. “Bacterial Pathogens and the Microbiome.” Otolaryngologic Clinics of North America, U.S. National Library of Medicine, Feb. 2017, www.ncbi.nlm.nih.gov/pubmed/27888914